| 產(chǎn)品編號(hào) | bsm-62527R |
| 英文名稱 | PTPN1/2 Recombinant Rabbit mAb |
| 中文名稱 | 蛋白酪氨酸磷酸酶非受體1/2重組兔單抗 |
| 別 名 | Protein tyrosine phosphatase non receptor type 2; PTN2; Ptpn2; PTPT; T cell protein tyrosine phosphatase; TC PTP; TCELLPTP; TCPTP; Tyrosine protein phosphatase non receptor type 2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000,Flow-Cyt=1:20-1:100,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50,48 kDa |
| 檢測(cè)分子量 | 40-48 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human PTPN1: 11-66 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. SWISS: P18031 Gene ID: 5770 蛋白酪氨酸磷酸酶1B（PTP1B）是一種胰島素信號(hào)的負(fù)性調(diào)節(jié)因子，與肥胖癥和2型糖尿病的發(fā)病及發(fā)展關(guān)系密切。對(duì)P-tyr基因敲除小鼠的研究表明，缺失PTP1B小鼠的胰島素敏感性明顯增加，并對(duì)肥胖有一定的抵抗作用，而另一些對(duì)動(dòng)物和人體的研究結(jié)果卻與此相反，發(fā)現(xiàn)PTP1B可通過引起胰島素抵抗、瘦素抵抗及影響脂代謝等而導(dǎo)致肥胖癥和2型糖尿病的發(fā)生。一些特異性的Ptyr小分子抑制劑已經(jīng)開發(fā)并用于肥胖和糖尿病的治療中。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with bsm-62527R monoclonal antibody, unconjugated (bsm-62527R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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