| 產(chǎn)品編號(hào) | bsm-62584R |
| 英文名稱 | MEF2A Recombinant Rabbit mAb |
| 中文名稱 | 肌細(xì)胞增強(qiáng)因子2重組兔單抗 |
| 別 名 | ADCAD1; MEF2; MEF2A; Myocyte enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor like protein 1. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測(cè)分子量 | 55 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human MEF2A: 465-507 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. SWISS: Q02078 Gene ID: 4205 MEF2是一種主要存在于肌細(xì)胞的轉(zhuǎn)錄因子，近來(lái)研究發(fā)現(xiàn)他也存在于肝臟，并且其表達(dá)及活性增加可能激活HSC，提高Ⅰ型膠原啟動(dòng)子的活性及刺激HSC的增生. 因此，MEF2可能在肝纖維化的發(fā)生，發(fā)展中發(fā)揮著重要作用。 |
| 產(chǎn)品圖片 |
Western blot analysis of HeLa cell lysate. Using MEF2A (bsm-62584R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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