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DBC2 Rabbit pAb (bs-4274R)  
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產品編號 bs-4274R
英文名稱 DBC2 Rabbit pAb
中文名稱 乳腺癌基因刪除蛋白2抗體
別    名 DBC 2; Deleted in breast cancer 2; Deleted in breast cancer 2 gene protein; E130206H14Rik; KIAA0717; p83; RBT2; RHBT2_HUMAN; Rho related BTB domain containing 2; Rho related BTB domain containing protein 2; Rho-related BTB domain containing 2; Rho-related BTB domain-containing protein 2; RHOBTB 2; Rhobtb2.  
Specific References  (1)     |     bs-4274R has been referenced in 1 publications.
[IF=7.032] Hyun Jeong Seok. et al. Novel miR-5088-5p promotes malignancy of breast cancer by inhibiting DBC2. Mol Ther-Nucl Acids. 2021 May;:  IHC ;  Mouse, Human.  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 83 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DBC2: 631-727/727 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome.

Tissue Specificity:
Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.

Similarity:
Belongs to the small GTPase superfamily. Rho family.
Contains 2 BTB (POZ) domains.

SWISS:
Q9BYZ6

Gene ID:
23221

Database links:

Entrez Gene: 23221 Human

Entrez Gene: 246710 Mouse

Omim: 607352 Human

SwissProt: Q9BYZ6 Human

SwissProt: Q91V93 Mouse

Unigene: 372688 Human

Unigene: 102367 Mouse



產品圖片
Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-DBC2 Polyclonal Antibody, Unconjugated(bs-4274R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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