| 產(chǎn)品編號(hào) | bs-9239R |
| 英文名稱 | RNF24 Rabbit pAb |
| 中文名稱 | 環(huán)指蛋白24抗體 |
| 別 名 | G1L; Goliath-like protein(C3HC4 type); RING finger protein 24; Rnf24; RNF24_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF24: 1-100/148 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF24 (ring finger protein 24), also known as Goliath-like protein (C3CH4 type) or G1L, is a single-pass membrane protein found in the Golgi apparatus, consisting of 148 amino acids. RNF24 causes intracellular retention of TRPCs, regulates insertion of TRPCs into the plasma membrane and interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. The RNF24 protein shares similarity with Drosophila Goliath protein and thus, may function as a transcription factor. Multiple transcript variants encoding different isoforms have been found for the RNF24 gene, which maps to human chromosome 20p13. Function: May play a role in TRPCs intracellular trafficking. Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Subcellular Location: Golgi apparatus membrane; Single-pass membrane protein. Similarity: Contains 1 RING-type zinc finger. SWISS: Q9Y225 Gene ID: 11237 Database links: Entrez Gene: 11237 Human SwissProt: Q9Y225 Human Unigene: 589884 Human |
