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IRAKM Rabbit pAb (bs-16695R)  
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50ul/1180.00元
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產(chǎn)品編號(hào) bs-16695R
英文名稱 IRAKM Rabbit pAb
中文名稱 白細(xì)胞介素1受體相關(guān)蛋白激酶M抗體
別    名 ASRT5; IL 1 receptor associated kinase M; IL-1 receptor-associated kinase M; IL1 receptor associated kinase M; Interleukin 1 Receptor Associated Kinase 3; Interleukin 1 Receptor Associated Kinase 3; Interleukin 1 Receptor Associated Kinase M; Interleukin 1 Receptor Associated Kinase M; Interleukin-1 receptor-associated kinase 3; IRAK 3; IRAK 3; IRAK M; IRAK-3; IRAK-M; IRAK3_HUMAN.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Pig,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 68 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRAKM: 151-250/596 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Tissue Specificity:
Expressed predominantly in peripheral blood lymphocytes.

DISEASE:
Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.

Similarity:
Belongs to the protein kinase superfamily.
TKL Ser/Thr protein kinase family. Pelle subfamily.
Contains 1 death domain.
Contains 1 protein kinase domain.

SWISS:
Q9Y616

Gene ID:
11213

Database links:

Entrez Gene: 11213 Human

Entrez Gene: 73914 Mouse

Entrez Gene: 314870 Rat

Omim: 604459 Human

SwissProt: Q9Y616 Human

SwissProt: Q8K4B2 Mouse

Unigene: 369265 Human

Unigene: 146194 Mouse

Unigene: 147737 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse skin); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IRAKM) Polyclonal Antibody, Unconjugated (bs-16695R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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