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PTPN18 Rabbit pAb (bs-4430R)  
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產品編號 bs-4430R
英文名稱 PTPN18 Rabbit pAb
中文名稱 腦源性磷酸酶PTPN18抗體
別    名 BDP 1; Brain derived phosphatase; Brain-derived phosphatase; Protein tyrosine phosphatase non receptor type 18; Protein tyrosine phosphatase non receptor type 18 brain derived; PTN18_HUMAN; PTP HSCF; PTPN 18; PTPN18; Tyrosine protein phosphatase non receptor type 18; Tyrosine-protein phosphatase non-receptor type 18.  
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Pig,Cow,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN18: 581-460/460 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Function:
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed in brain, colon and several tumor-derived cell lines.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

SWISS:
Q99952

Gene ID:
26469

Database links:

Entrez Gene: 26469 Human

Omim: 606587 Human

SwissProt: Q99952 Human

Unigene: 516390 Human

Unigene: 726000 Human



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTPN18) Polyclonal Antibody, Unconjugated (bs-4430R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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