| 產(chǎn)品編號(hào) | bsm-60790M |
| 英文名稱 | CD57 Mouse mAb |
| 中文名稱 | 髓鞘相關(guān)糖蛋白（CD57）單克隆抗體 |
| 別 名 | 3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; beta 1 3 glucuronyltransferase 1; beta-1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GlcAT P; GlcAT-P; GLCATP; GlcUAT P; GlcUAT-P; GlcUATP; Glucuronosyltransferase P; HNK 1; HNK1; LEU7; LEU7 antigen; NK 1; NK1; UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase; UDP-GlcUA:glycoprotein beta-1. |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | G14H3 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | IHC-P=1:20-100,IHC-F=1:20-100,IF=1:20-100
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 38 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD57 |
| 亞 型 | IgG1, k |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | PBS, Glycerol, BSA. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Subunit: Homodimer (Potential). Subcellular Location: Golgi apparatus membrane; Single-pass type II membrane protein. Tissue Specificity: Mainly expressed in the brain. Similarity: Belongs to the glycosyltransferase 43 family. SWISS: Q9P2W7 Gene ID: 27087 Database links: Entrez Gene: 27087 Human Omim: 151290 Human SwissProt: Q9P2W7 Human Unigene: 381050 Human CD57是一種分子量為110KD的糖蛋白,它是自然殺傷細(xì)胞(NK)和殺傷細(xì)胞的特異性表面抗原。CD57表達(dá)于15-20%的外周血單核細(xì)胞，60%的NK活化細(xì)胞以及T細(xì)胞亞群。該抗體可以標(biāo)記NK細(xì)胞，也可識(shí)別非淋巴組織的一些細(xì)胞?？捎糜贜K細(xì)胞介導(dǎo)的細(xì)胞毒、NK細(xì)胞及T細(xì)胞亞群的功能等方面的研究，也可標(biāo)記神經(jīng)內(nèi)分泌細(xì)胞及其腫瘤。 |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded Human Prostate Tumor; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD57 Monoclonal Antibody, Unconjugated(bsm-60790M) at 1:100 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD57 Monoclonal Antibody, Unconjugated(bsm-60790M) at 1:100 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Chronic tonsillitis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD57 Monoclonal Antibody, Unconjugated(bsm-60790M) at 1:100 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Tonsil; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD57 Monoclonal Antibody, Unconjugated(bsm-60790M) at 1:100 overnight at 4°C, followed by conjugation to the bs-40296G-HRP and DAB (C-0010) staining.
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