| 產(chǎn)品編號(hào) | bs-42054R-BF594 |
| 英文名稱(chēng) | CD36 |
| 中文名稱(chēng) | BF594標(biāo)記的CD36抗體 |
| 別 名 | Platelet glycoprotein 4; PAS-4; Platelet glycoprotein IV; Glycoprotein IIIb; GPIV; GPIIIB; GP3B; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor; CD_antigen: GP4; CD36_HUMAN. |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Mouse |
| 產(chǎn)品應(yīng)用 | IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant mouse CD36 protein: 30-439/472 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Subunit: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes. Post-translational modifications: N-glycosylated and O-glycosylated with a ratio of 2:1. DISEASE: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938]. Similarity: Belongs to the CD36 family. Database links: CD36屬一種多功能細(xì)胞膜受體，CD36參與長(zhǎng)鏈脂肪酸的吸附和調(diào)節(jié)細(xì)胞凋亡殘物的清理和巨噬細(xì)胞的吞噬作用， 屬于一種抗蛋白酶血小板膜表面糖蛋白。 CD36 廣泛在單核細(xì)胞、巨噬細(xì)胞、內(nèi)皮層細(xì)胞、血小板、紅細(xì)胞前板、脂肪細(xì)胞、肌肉細(xì)胞以及乳腺內(nèi)皮層細(xì)胞中有不同的表達(dá)。CD36抗原是血小板反應(yīng)素的配體，兩者結(jié)合后產(chǎn)生抑制腫瘤血管生成的效應(yīng)。 |
